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 Technology
Chiral Intermediates
Synthetech takes its specialty amino acids "downstream" to the manufacture of many complex chiral intermediates. Multiple adjacent chiral centers, required for an increasing number of developmental drugs, can be accessed through amino acid derivative chemistry. The chemistry required for these derivatives, including hydrogenation, Grignard and hydride additions, condensations reactions and others, has been practiced on a multi-ton scale at Synthetech. Most of this chemistry is carried out under confidentiality protocol.
Peptide Fragments
Synthetech has also developed expertise in the solution phase manufacture of small peptides, the ultimate products most often derived from amino acids. The choices of protection group,  activating group, order of addition and coupling agent lead to numerous alternate potential peptide synthesis routes. Our experience in the manufacture of the protected amino acids as well as solution phase coupling allows us to quickly target the most cost effective process.
Specialty Amino Acids
Specialty amino acids, their derivatives, and small peptides continue to gain importance in drug development. Reliable, cost-effective commercial supply of these intermediates is crucial for a successful drug launch. Synthetech employs the most cost-effective manufacturing processes to provide high-quality, reproducible specialty amino acids on an industrial scale. We have developed expertise in both enzymatic and chemical routes to specialty amino acids.
 The acylase route is a well-established, cost-effective process for producing both enantiomers of many specialty amino acids. Hydantoinase enzymes can be used to provide high yields of high-purity D-amino acids. Other enzymes, including transaminase and nitrilase, are also evaluated in select situations.
Non-enzymatic (chemical) processes, including asymmetric hydrogenation, chiral auxiliary and classical resolution methods, are also employed by Synthetech.
Protected Amino Acids
Both solid phase and solution phase peptide syntheses are demanding a growing array of protected amino acids. These peptide syntheses require amine protection, side-chain protection, and often acid activation or protection. The addition order of the protecting groups can have a significant influence on both the cost and quality of a particular derivative. Synthetech has extensive experience in kilos-to-tons manufacturing of this wide array of protected amino acids.
Resins for SPPS
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Synthetech's Unique Strengths
Sole US-based large-scale manufacturer of SPPS resins with capacity exceeding 15,000 gallons.
Copolymerization technology affords excellent batch-to-batch consistency.
Backward integrated into production high-quality amino acid derivatives specialty amino acids for loading onto new SPPS resin product line.
Certified non-animal / non-human product line, including peptide fragments, specialty amino acids, amino acid derivatives, preloaded resins, and SPPS resins. |
Synthetech expanded its core competency in 2006 to include a range of cross-linked and functionalized polymeric resins used widely in solid phase peptide synthesis (SPPS). This technology includes the procedure to attach the specified terminal amino acid to the resin, offering a key value-added service to peptide customers.
Our range of functionalized resins are used to produce peptide acids or peptide amides for combinatorial chemistry using an Fmoc or Boc synthetic method. They offer excellent batch-to-batch reproduction, and controlled, optimized particle sizes. These benefits promote improved product quality and increased yields. Resins are available from lab to commercial scale.
Our resin portfolio will include Merrifield, Aminomethyl, MBHA, Wang, 2-CTC and a wide range of specialty resins.
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